Aramak
  • Aramak
  • Storyboardlarım

journal article #3

Bir Öykü Panosu Oluşturun
Bu Öykü Panosunu kopyala
journal article #3
Storyboard That

Kendi Storyboard'unuzu oluşturun

Ücretsiz deneyin!

Kendi Storyboard'unuzu oluşturun

Ücretsiz deneyin!

Öykü Penceresi Metni

  • Cystic Fibrosis is a genetic disease that causes thick secretions to accumulate in airways, digestive organs, and sperm ducts.
  • 
  •  CFTR= cystic fibrosis transmembrane conductance regulator
  • The key defect in cystic fibrosis is the loss of the chloride conductance, but mutation of the cystic fibrosis gene, the CFTR has many effects on cell physiology
  • Loss of conductance through the chloride channel reduces fluid secretion leads to
  • The loss of the epithelial chloride conductance and some of the symptoms of cystic fibrosis can be explained by...
  • 
  • airway obstruction by condensed macromolecules; salt absorption is also compromised in some tissues
  • How does loss of CFTR cause cystic fibrosis??
  • The CFTR may transport ATP and bicarbonate ions, CFTR can also affect other membrane molecules> could trigger complex downstream events.
  • This leads to cells that line the passages of lungs and other organs to produce mucus that is unusually thick .
  • Meaning- mutations in the CFTR gene disrupt the function of chloride channels. Prevents them from regulating the flow of chloride ions and water across the cell membrane.
  • Also studies of cystic fibrosis by gene targeting along with genotype/phenotype analysis of cystic fibrosis patients> evidence that the loss of the CFTR is primarily responsible for cystic fibrosis disease!
  • So cool and interesting!!!!! 
30 Milyondan Fazla Storyboard Oluşturuldu