Genetics and Covid-19
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- However, what's important is finding the actual root cause for severe cases as well as detailed molecular, cellular, tissue, and body-level mechanisms underlying life-threatening COVID-19
- Yeah, the main risk factors for severe Covid are being male, elderly, or immunocompromised.
- Hypothesis: life-threatening COVID-19 in some or most patients may be caused by monogenic inborn errors of immunity to SARS-CoV-2
- Hey! Aren't there other reasons than genetics that people get Covid?
- They considered three loci identified as mutated :TLR3,IRF7, andIRF9 as well as ten loci that were mutated in other viruses but connected to the main 3.
- They found an enrichment in variants predicted to be loss-of-function (pLOF), with a minor allele frequency <0.001
- Yeah! They did, it seems highly possible that genetic errors, such as inborn INF errors are an emerging cause for more severe Covid.
- The variants represent both autosomal recessive and autosomal positive traits so nothing can be distinguished from that. It is important to note that both can be negatively affected.
- So.. Did they test the hypothesis? Is it true?
- All information thanks to: Zhang, Q., Bastard, P., Liu, Z., & Le Pen, J. (2020, September 24).Inborn errors of type I IFN immunity in patients with life-threatening covid-19[Fact sheet]. Science. Retrieved January 21, 2022, from https://www.science.org/doi/10.1126/science.abd4570
- This discovery reveals essential roles for both the double-stranded RNA sensor TLR3 and type I IFN cell-intrinsic immunity in the control of SARS-CoV-2 infection
- At least 3.5% of patients with life-threatening COVID-19 pneumonia had known deficiencies or new genetic defects at eight of the 13 candidate loci.
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- NO, these people had never been hospitalized due to their reaction to a viral illness before. This was a novel reaction.
- Giving Type 1 IFN may be beneficial to some patients in treating SARS-CoV-2 infections, especially early on in the virus's course.
- Wait! Did these people have a medical history? I heard that affects your risk level.
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