nuclein
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- Albrecht Kossel is a German biochemist in study of genetics. He was a research scientist under Hoppe Seyler.
- Hi this is Kossel , my field of work is physiological chemistry. I started my investigation on cell nucleus and further studied about proteins and their alternatives .
- Hoppe's research was based on concerning an acidic substance that has been firstly isolated.
- Yes Mr.Hoppe but these doesnt look like other cellular substance which we already came through
- these acidic substance consists of considerable amount of phosphorous, but with high acidity.
- Chemical analysis showed first that in many cases nucleic substances are broken down into two parts, one having the character of a protein. This part possesses no other atom groups than the usual proteins. Hoppe-Seyler’s, was able to isolate these nuclei and he found in them a substance very rich in phosphorus which he called “Nucleïn”.
- Yes, this substance called nuclein consists of protein component and non-protein component.
- Further isolated and described the non-protein component.
- it has been given the name of “nucleic acid“
- Kossel and his students used hydrolysis and other techniques to chemically analyze the nucleic acids, thus discovering their component compounds: adenine, cytosine, guanine, thymine, and uracil. Albrecht Kossel discovered that these acids were composed of five nitrogen bases: adenine, cytosine, guanine, thymine, and uracil. These compounds are now known collectively as nucleobases, and they provide the molecular structure necessary in the formation of stable DNA and RNA molecules
- Kossel was awarded the Nobel Prize in Physiology or Medicine in 1910 for his research in cell biology, the chemical composition of the cell nucleus, and for his work in isolating and describing nucleic acids.
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