Harriet wrote Uncle Tom's cabin in hopes of persuading pro-slavery people, politicians and slave owners to abolish slavery. The story was based off the former slave Josiah Henson. Uncle Tom's Cabin became a very popular book and changed some peoples views. Stowe adapted her views of abolishment from her father.
In 1872 Harriets brother Henry was charged with having an affair with a female parishioner. This brought national attention to the Beecher family but Harriet remained on her brothers side and said he was innocent. 
Harriet Beecher Stowe had many properties throughout the United States and into Florida which at the time belonged to Spain. She had a house in Brunswick Maine where she wrote Uncle Tom's Cabin then in 2001 Bowdoin College bought the house to restore it, a house in Hartford Connecticut where she spent her later years, and a house in Jacksonville Florida where she wrote the book "Palmetto Leaves".