GBM
Süžeeskeem Tekst
- RPA BRAIN CANCER WARD
- RPA BRAIN CANCER CENTRE
- Diagnosis: Grade IV malignant glioblastoma multiformeHigh metastatic activity observed with fibrillary astrocytomaMetastasis predominantly concentrated in the frontal cortex PET scans demonstrate consistent tumorigenic metabolism of astrocytes
- Prognosis for Patient: Daniel BrawleyDate: 26/01/2050Age: 56
- Neoplastic growth in frontal lobe
- PVS- RIPO TREATMENT SCHEME
- Poliovirus interjection
- Reduced tumour
- Daniel Brawley, a 56 year old male, has presented to the RPA Brain Cancer ward after exacerbated clinical presentation of symptoms similar to a stroke (nausea and headaches). In 2020, he was diagnosed with low- grade astrocytoma, but due to deficiencies in technological advancement for long- term brain cancer treatment at the time, his condition was untreated.
- After examining his patient records, nurses ordered an immediate PET scan of Daniel's brain, and aggressive metastatic neoplasms were detected in the frontal lobe. He was subsequently diagnosed with grade IV Glioblastoma Multiforme (GBM), an almost incurable and aggressive brain cancer characterised by malignant astrocyte tumorigenesis.
- Before PVS- RIPO
- Patient #132: Daniel Brawley
- RPA BRAIN CANCER CENTRE
- 6 Months Post PVS- RIPO
- Nurses suggested the newly approved PVS- RIPO treatment for Daniel, which involves intracebral transmission of a modified oncolytic poliovirus that can penetrate and lyse tumours, mitigating metastasis. The virus can be altered according to Daniel's personal cancer profile, marking a revolution in oncotherapy, as prior to 2050, there were significant deficiencies in employment of personalised medicine for oncotherapeutics.
- RPA 2050
- Patient #132: PET scan of frontal cortex showing neoplastic spread
- Upon consensus, Daniel began treatment, which was initiated by first introducing the virus into the tumour via convection enhanced delivery (CED). This involved a small surgical incision to induce catheter into the frontal lobe, through which the virus can be administered intratumorally.
- Six months following the PVS- RIPO procedure, there was complete eradication of the established metastases in the frontal lobe, and anti- tumour immunity caused by the poliovirus was established. Therefore, Daniel's prognosis was downgraded to a grade I GBM, under the RPA Cancer Classification Scheme. Monthly brain scans were still taken.
- Following Daniel's one year brain scan, he was urgently contacted by the RPA, whose nurses had discovered rapid and aggressive regrowth of the GBM tumours. His prognosis was immediately reverted to a stage IV aggressive GBM, and he's now the seventh patient to unsuccessfully respond to the PVS- RIPO treatment.
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