Blood clot formation
Storyboard Text
- whats that?
- Hey doc, my brother fell at basketball practice and cut his knee open. It was bleeding pretty bad, but then after a few minutes it magically stopped!
- Haha, although it does look pretty magical, we do have to give the credit to our bodies ability to clot our blood.
- Hey guys! Whats going on? It sounded quite urgent.
- When there is damage to the blood vessel's cells, the cells expressing TF binds to the initial clotting factor in the clotting cascade, VIIa, resulting in a TF:VIIa complex that activates other clotting factors like Thrombin nearing the end of the cascade.
- blood vessels are very important to our circulatory system, which transports blood, platelets and more all around our body. And when these blood vessels become damaged, like your brother did when he cut his knee, a process called hemostasis, or blood clotting, occurs to prevent too much blood from leaking out.
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- On the surface of our blood vessel cells there is a glycoprotien called TF.
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- TF:VIIa complex
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- Ultimately, the production of Thrombin leads to the activation of important clotting factors; Fibrin protein and activated platelets.
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- When the vessel is damaged, it is exposed to the chemical, collagen, that attracts the now activated platelets in the bloodstream to the area of injury, forming a weak blockage. To make ever it stronger, the sticky fibrin fibers made before and other components in the bloodstream form around the platelets.
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